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      Boutique Hotels in Panama City

      Curated selection of 15+ Panama City boutique hotels with unique designs, spa access, and prime locations. Compare top-rated picks and exclusive deals now.

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      1-16 out of 16
      Sort by: high popularity
      • Price: low to high
      • Price: high to low
      • Guest rating: high to low
      • Popularity: high to low
      Riu Plaza PanamaHotel
      8.7
      Great9040 total reviews
      our site & Booking.com
      Map
      1605 yd from City Center664 yd from Balboa Boutiques
      Conference RoomsSushi BarTurkish Bath
      • 23 conference rooms for 1,300+ guests
      • Sushi Lounge Studio 50 on-site
      • Evening entertainment and happy hour
      FromUS$ 107 /nightSelect
      Jw Marriott PanamaHotel
      8.9
      Great943 total reviews
      our site & Booking.com
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      1.6 mi from City Center1337 yd from Multiplaza Pacific Mall
      Rooftop PoolDesigner ShopsWaterfront Dining
      • Infinity pool with Panama Bay views
      • Live ceviche bar on-site
      • 24-hour spa and fitness center
      FromUS$ 139 /nightSelect
      American Trade HotelHotel
      8.7
      Great679 total reviews
      our site & Booking.com
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      3.1 mi from City Center344 yd from Presidential Palace
      Jazz ClubOutdoor PoolBanquet Facilities
      • Live jazz club on-site
      • UNESCO Casco Viejo location
      • Colonial-meets-modern design
      FromUS$ 254 /nightSelect
      Hyatt Regency Panama CityHotel
      9.0
      Perfect511 total reviews
      our site & Booking.com
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      1676 yd from City Center847 yd from Coastal Beltway
      CasinoFull-service SpaOutdoor Pool
      • On-site casino and lobby bar
      • Full-service spa with steam room
      • Corvina & Caña restaurant
      FromUS$ 104 /nightSelect
      Megapolis Hotel PanamaHotel
      8.5
      Great4985 total reviews
      our site & Booking.com
      Map
      1.2 mi from City Center353 yd from Balboa Boutiques
      Infinity PoolMajestic CasinoSky Bar
      • Infinity pool with panoramic city views
      • On-site casino and Megapolis Outlets
      • Signature Sound of Your Stay amenity
      FromUS$ 92 /nightSelect
      Waldorf Astoria PanamaHotel
      8.7
      Great320 total reviews
      our site & Booking.com
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      1.3 mi from City Center250 yd from Coastal Beltway
      Outdoor PoolSpa & WellnessPool Bar
      • Award-winning spa with local treatments
      • Ocean-view pool bar and lounge
      • Complimentary shuttle within 2 km
      FromUS$ 125 /nightSelect
      The Westin PanamaHotel
      8.6
      Great274 total reviews
      our site & Booking.com
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      3.2 mi from City Center1256 yd from Panama Viejo Cathedral
      Rooftop PoolSensory SpaExecutive Lounge
      • Rooftop garden with outdoor pool
      • Sensory Spa by Clarins
      • WestinWORKOUT fitness studio
      FromUS$ 149 /nightSelect
      Bristol Panama, A Registry Collection HotelHotel
      9.0
      Perfect1183 total reviews
      our site & Booking.com
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      1.0 mi from City Center739 yd from Coastal Beltway
      Salsipuedes RestaurantFull-service SpaView Pool
      • Award-winning Panamanian fusion cuisine
      • Latin American art on display
      • Spa with panoramic city views
      FromUS$ 99 /nightSelect
      Le Meridien PanamaHotel
      8.1
      Great450 total reviews
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      1.3 mi from City Center165 yd from Coastal Beltway
      Clarins SpaOutdoor PoolFusion Restaurant
      • Sensory Spa by Clarins
      • Glass atrium lobby
      • Overlooks Panama Bay
      FromUS$ 89 /nightSelect
      Sortis Hotel, Spa & Casino, Autograph CollectionHotel
      8.7
      Great463 total reviews
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      874 yd from City Center658 yd from Parque Nacional Soberanía
      CasinoSpaLebanese Restaurant
      • Largest casino in Panama City
      • Authentic Lebanese cuisine on-site
      • Spa with vitality pool and wave room
      FromUS$ 109 /nightSelect
      Tantalo Hotel - Kitchen - RoofbarHotel
      8.1
      Great770 total reviews
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      3.1 mi from City Center184 yd from Presidential Palace
      Rooftop BarArt SuitesEvent Space
      • Iconic rooftop bar with nightly DJs
      • Artistic suites by local Panamanian artists
      • Sustainable design empowering women
      FromUS$ 95 /nightSelect
      Aloft By Marriott PanamaHotel
      8.2
      Great942 total reviews
      our site & Booking.com
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      1.2 mi from City Center155 yd from ATLAPA Conventions Center
      Outdoor PoolFitness CentreGames Room
      • Vibrant WXYZ bar with games
      • 24-hour Re:Fuel snack bar
      • Pet-friendly policies for all guests
      FromUS$ 76 /nightSelect
      Decapolis Hotel Panama CityHotel
      8.1
      Great7386 total reviews
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      1.2 mi from City Center415 yd from Balboa Boutiques
      Rooftop DiningOn-site CasinoTurkish Bath
      • Rooftop dining with cityscape views
      • On-site casino and entertainment
      • Spa with Turkish bath
      FromUS$ 71 /nightSelect
      Tryp By Wyndham Panama CentroHotel
      8.5
      Great4499 total reviews
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      1633 yd from City Center629 yd from Parque Nacional Soberanía
      Rooftop PoolFitness CentreSpa
      • Rooftop pool with city views
      • On-site Mediterranean Gastro Bar
      • 250m from El Carmen Metro
      FromUS$ 63 /nightSelect
      Marriott Executive Apartments Panama City, FinisterreHotel
      8.1
      Great252 total reviews
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      1.3 mi from City Center719 yd from Coastal Beltway
      Full KitchenOutdoor PoolFree Parking
      • Apartment-style suites with kitchens
      • Outdoor pool with ocean views
      • Pet-friendly in business district
      FromUS$ 119 /nightSelect
      Riande Urban HotelHotel
      8.3
      Great1756 total reviews
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      1254 yd from City Center347 yd from Parque Nacional Soberanía
      Outdoor PoolBiergartenFitness Center
      • Art Deco style with modern flair
      • On-site Biergarten with craft brews
      • Large sundeck with outdoor pool
      FromUS$ 44 /nightSelect

      Explore Hotels in Panama City by Feature

      Districts
      Casco Viejo / Bella Vista / Calidonia / Obarrio / Marbella / Ancon
      Star rating
      5 star
      Hotel themes
      Pet-friendly / Luxury

      Panama City's boutique hotel scene combines modern luxury with local character. Properties like the Bristol Panama, A Registry Collection Hotel in the financial district offer soundproofed rooms with spa access and gourmet Panamanian cuisine. The Hyatt Regency Panama City, a 20-story tower near the bay, features an outdoor pool and casino, while the American Trade Hotel in Casco Viejo brings a jazz bar and historic charm. Budget expectations range from $150 to $350 per night for these curated stays.

      For travelers seeking design-forward options, the Waldorf Astoria Panama sits 50 meters from Balboa Avenue with city views, and the JW Marriott Panama provides balconies overlooking the bay. The 66-story Megapolis Hotel Panama offers an infinity pool and proximity to the Cinta Costera Park, while the Sortis Hotel, Spa & Casino, Autograph Collection adds a casino and city views. Most properties include outdoor pools, fitness centers, and on-site dining, with many located in the financial district or near the Panama Canal.