Luxury hotels in Cusco occupy meticulously restored colonial mansions in the historic center. Most offer oxygen-enriched rooms to combat altitude sickness, round-the-clock coca tea, and guided heritage tours. Budget expectations start at $200+ per night, and the best areas to stay are steps from Plaza de Armas or in the artisan neighborhood of San Blas.
Among top-rated properties, Palacio del Inka (92 Superb) sits opposite Koricancha and features an indoor pool and complimentary pisco lessons. JW Marriott El Convento (93 Superb) occupies a 16th-century convent with oxygen suites and a destination fee covering breakfast and spa vouchers. For intimate stays, Inkaterra La Casona (91 Superb) offers marble fireplaces and private guides, while Antigua Casona San Blas (98 Exceptional) provides a hyperbaric chamber and yoga studio ideal for altitude adjustment.