Vacation Rentals in Saint Charles, MO

Compare vacation rentals and Airbnbs in St Charles, MO near Historic Main Street. Check amenities like full kitchens and parking, then book your stay.

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Rooms and Guests2 Guests, 1 room
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Rooms and Guests2 Guests, 1 room
1Filter & Sort
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Check-in
Mon, 09 Nov
-
Check-out
Tue, 10 Nov
Rooms and Guests2 Guests, 1 room
1Filter & Sort
View map
View map
1-8 out of 8
Sort by: high popularity
  • Price: low to high
  • Price: high to low
  • Guest rating: high to low
  • Popularity: high to low
7.1
Very good
Map
1.9 mi from City Center104 yd from Charles County Parks Dept
Full KitchenFree ParkingPets Allowed
  • In-room full kitchen
  • Pets allowed on-site
  • 24-hour front desk
FromUS$ 160 /nightSelect
8.5
Great
Map
2.0 mi from City Center226 yd from Charles County Parks Dept
Full KitchenBalconyPets Allowed
  • Spacious apartment for up to 8
  • Full kitchen with dishwasher and oven
  • Pets allowed on premises
FromUS$ 269 /nightSelect
7.4
Very good
Map
1.8 mi from City Center298 yd from Charles County Parks Dept
FromUS$ 310 /nightSelect
7.9
Very good
Map
2.0 mi from City Center172 yd from Charles County Parks Dept
Private GarageFull KitchenPatio Barbecue
  • Private garage parking on-site
  • Historic two-bedroom apartment with kitchen
  • Private patio with barbecue
FromUS$ 197 /nightSelect
7.4
Very good
Map
2.0 mi from City Center542 yd from Living Word Bible College
FromUS$ 287 /nightSelect
8.2
Great
Map
2.0 mi from City Center172 yd from Charles County Parks Dept
Full KitchenFitness CenterPets Allowed
  • Fully equipped kitchen
  • Pet-friendly apartments
  • On-site fitness center
FromUS$ 183 /nightSelect
7.7
Very good
Map
1.8 mi from City Center92 yd from Lewis and Clark Ctr
FromUS$ 330 /nightSelect
9.0
Perfect
Map
1.7 mi from City Center289 yd from Living Word Bible College
Fitness RoomChildren's PlaygroundFully Equipped Kitchen
  • Dog-friendly holiday home
  • Fully equipped kitchen
  • On-site bowling and fishing
FromUS$ 235 /nightSelect

Vacation rentals in Saint Charles, MO, offer an alternative to traditional hotels, with a focus on space and home-like amenities. Properties are concentrated around Historic Main Street, placing guests within walking distance of dining, shopping, and local landmarks like the Foundry Art Centre and Missouri Artists On Main. These rentals typically include fully equipped kitchens, free WiFi, and free parking, making them suitable for families or extended trips.

Among the top-rated options, the Historic Main St 1BR provides a Good-rated apartment with a 24-hour front desk and spacious living area, ideal for budget-conscious travelers. The Historic Main St 2BR, rated Fabulous, features three bathrooms and a washing machine, located steps from Main Street shops. For guests traveling with pets, the Superb-rated Dog-Friendly House offers a fitness room, children's playground, and a patio. Both the apartments and the house are within 10-16 km of St. Louis Lambert International Airport.